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Kazuhide Higuchi Selected Research

Rabeprazole (Aciphex)

12/2019Cost-utility analysis of a 'vonoprazan-first' strategy versus 'esomeprazole- or rabeprazole-first' strategy in GERD.
11/2019Efficacy and safety of hangeshashinto for treatment of GERD refractory to proton pump inhibitors : Usual dose proton pump inhibitors plus hangeshashinto versus double-dose proton pump inhibitors: randomized, multicenter open label exploratory study.
8/2019Vonoprazan versus proton-pump inhibitors for healing gastroesophageal reflux disease: A systematic review.
3/2018Therapy of gastroesophageal reflux disease and functional dyspepsia overlaps with symptoms after usual-dose proton pump inhibitor: Acotiamide plus usual-dose proton pump inhibitor versus double-dose proton pump inhibitor.
1/2018Vonoprazan, a Novel Potassium-Competitive Acid Blocker, Should Be Used for the Helicobacter pylori Eradication Therapy as First Choice: A Large Sample Study of Vonoprazan in Real World Compared with Our Randomized Control Trial Using Second-Generation Proton Pump Inhibitors for Helicobacter pylori Eradication Therapy.
1/2017Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin.
11/2015Recent effectiveness of proton pump inhibitors for severe reflux esophagitis: the first multicenter prospective study in Japan.
5/2015Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel-group, multicenter, extension clinical trial.
1/2015Characteristics of refractory gastroesophageal reflux disease (GERD) symptoms -is switching proton pump inhibitors based on the patient's CYP2C19 genotype an effective management strategy?
7/2014Clinical characteristics of elderly patients with proton pump inhibitor-refractory non-erosive reflux disease from the G-PRIDE study who responded to rikkunshito.
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Kazuhide Higuchi Research Topics

Disease

40Neoplasms (Cancer)
01/2022 - 05/2003
29Ulcer
01/2020 - 07/2002
24Gastroesophageal Reflux (GERD)
11/2021 - 05/2004
21Ulcerative Colitis
04/2022 - 01/2003
20Hemorrhage
03/2022 - 01/2008
20Pathologic Constriction (Stenosis)
01/2022 - 08/2004
18Stomach Neoplasms (Stomach Cancer)
11/2022 - 10/2005
14Stomach Ulcer (Gastric Ulcer)
07/2015 - 07/2002
13Fistula
11/2022 - 05/2014
13Infections
01/2020 - 07/2002
11Inflammation (Inflammations)
01/2019 - 05/2003
11Colitis
01/2019 - 05/2003
10Hepatocellular Carcinoma (Hepatoma)
06/2022 - 01/2015
10Peptic Esophagitis (Reflux Esophagitis)
01/2021 - 01/2003
10Peptic Ulcer (Peptic Ulcers)
05/2015 - 09/2002
10Crohn Disease (Crohn's Disease)
01/2015 - 01/2003
9Carcinogenesis
05/2021 - 02/2010
8Esophagitis
08/2019 - 01/2003
7Neoplasm Metastasis (Metastasis)
01/2022 - 10/2019
7Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
05/2015 - 08/2002
6Liver Diseases (Liver Disease)
09/2021 - 01/2013
6Cholangitis
05/2021 - 01/2016
6Dyspepsia (Indigestion)
01/2021 - 11/2015
6Non-alcoholic Fatty Liver Disease
01/2021 - 02/2010
6Pancreatitis
04/2020 - 05/2014
6Fibrosis (Cirrhosis)
03/2020 - 11/2009
6Wounds and Injuries (Trauma)
03/2018 - 10/2004
6Heartburn (Pyrosis)
03/2018 - 01/2005
5Necrosis
06/2022 - 11/2016
5Liver Cirrhosis (Hepatic Cirrhosis)
12/2021 - 09/2014
5Sepsis (Septicemia)
05/2021 - 01/2014
5Duodenal Obstruction
03/2021 - 09/2014
5Pancreatic Neoplasms (Pancreatic Cancer)
01/2021 - 09/2014
5Colorectal Neoplasms (Colorectal Cancer)
08/2020 - 01/2005
5Carcinoma (Carcinomatosis)
01/2020 - 11/2011
5Esophageal and Gastric Varices (Esophageal Varices)
09/2014 - 10/2002
4Ascites
01/2022 - 01/2020
4Dysbiosis
09/2021 - 09/2017
4Peritonitis
09/2021 - 05/2014
4Rheumatoid Arthritis
12/2020 - 01/2008
4Disease Progression
03/2020 - 05/2005
4Abdominal Pain (Pain, Abdominal)
03/2020 - 08/2002
3Mitochondrial Diseases (Mitochondrial Disease)
10/2021 - 05/2014
3Disseminated Intravascular Coagulation
05/2021 - 01/2018
3Diabetes Mellitus
05/2021 - 01/2010
3Obesity
05/2021 - 01/2011
3Vomiting
03/2021 - 11/2017
3Atrophic Gastritis
01/2021 - 04/2003
3Body Weight (Weight, Body)
01/2021 - 01/2013

Drug/Important Bio-Agent (IBA)

37Proton Pump InhibitorsIBA
11/2021 - 03/2004
23Pharmaceutical PreparationsIBA
01/2022 - 07/2002
18Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
03/2018 - 08/2002
16Capsules (Microcapsules)IBA
06/2021 - 01/2006
16AcidsIBA
11/2019 - 01/2003
13Rabeprazole (Aciphex)FDA Link
12/2019 - 01/2003
11MetalsIBA
06/2022 - 09/2014
10CytokinesIBA
10/2021 - 01/2003
9Proteins (Proteins, Gene)FDA Link
12/2021 - 01/2003
9Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
11/2021 - 11/2008
8AntigensIBA
05/2018 - 08/2002
7Irinotecan (Camptosar)FDA LinkGeneric
03/2021 - 07/2010
6Fluorouracil (Carac)FDA LinkGeneric
03/2021 - 01/2004
6Indomethacin (Indometacin)FDA LinkGeneric
12/2020 - 01/2004
6Dextran SulfateIBA
01/2019 - 01/2005
6rebamipideIBA
07/2015 - 07/2002
6Messenger RNA (mRNA)IBA
01/2010 - 01/2003
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2009 - 01/2003
5Oxaliplatin (Eloxatin)FDA LinkGeneric
03/2021 - 10/2011
5SteroidsIBA
10/2020 - 05/2003
51- (5- (2- fluorophenyl)- 1- (pyridin- 3- ylsulfonyl)- 1H- pyrrol- 3- yl)- N- methylmethanamineIBA
12/2019 - 01/2018
5Biological ProductsIBA
02/2016 - 10/2004
5ProstaglandinsIBA
07/2015 - 02/2010
4Tacrolimus (Prograf)FDA LinkGeneric
01/2022 - 01/2013
4Anti-Bacterial Agents (Antibiotics)IBA
09/2021 - 01/2014
4Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019 - 08/2006
4EnzymesIBA
01/2019 - 09/2003
4Lansoprazole (Prevacid)FDA LinkGeneric
04/2018 - 01/2005
4liu-jun-zi-tangIBA
08/2016 - 03/2012
4Prednisolone (Predate)FDA LinkGeneric
01/2016 - 11/2003
4Adrenal Cortex Hormones (Corticosteroids)IBA
01/2016 - 01/2008
4Omeprazole (Prilosec)FDA LinkGeneric
11/2015 - 01/2006
3NivolumabIBA
01/2022 - 01/2019
3AntibodiesIBA
01/2022 - 09/2003
3Serum AlbuminIBA
01/2022 - 10/2020
3Glucose (Dextrose)FDA LinkGeneric
12/2021 - 01/2018
3ThrombomodulinIBA
05/2021 - 01/2018
3Dacarbazine (DIC)FDA LinkGeneric
05/2021 - 01/2018
3Therapeutic UsesIBA
01/2021 - 12/2008

Therapy/Procedure

58Therapeutics
03/2022 - 09/2002
34Stents
11/2022 - 01/2014
13Drug Therapy (Chemotherapy)
03/2021 - 09/2007
11Aftercare (After-Treatment)
01/2021 - 10/2002
8Hepatectomy
06/2022 - 10/2019
7Self Expandable Metallic Stents
11/2022 - 07/2014
5Catheters
01/2022 - 01/2003
5Gastrectomy
11/2021 - 02/2018
4Transjugular Intrahepatic Portasystemic Shunt
03/2021 - 01/2015
4Neoadjuvant Therapy
03/2021 - 07/2010
3Length of Stay
09/2021 - 01/2016
3Radiofrequency Ablation
06/2021 - 01/2016